Journal: Acta Neurochirurgica

Article Title: Methodological and ethical challenges in the use of focused ultrasound for blood–brain barrier disruption in neuro-oncology

doi: 10.1007/s00701-023-05782-5

Figure Lengend Snippet: Summary of study characteristics and methodology of published original studies on therapeutic FUS for BBB modulation

Article Snippet: Hsu et al. (2013)[ ] , 0 , Taiwan , NR , 74 , Mouse brain ( in & ex vivo ) , Drug : Recombinant adeno-associated viral (rAAV) vectors Device : 0.3 mL/kg microbubbles bolus injection (SonoVueH SF6-coated ultrasound microbubbles, mean diameter 2–5 mm, 2.5 mg/kg, Bracco Diagnostics Inc., Milan, Italy; 0.03 mL/kg for clinical diagnostic application); ultrasonic energy was delivered to the brain transcranially using a spherically focused transducer (Imasonics, Besancon, France; diameter = 60 mm, radius of curvature = 80 mm, frequency = 1.5 MHz) , 1–6 weeks.

Techniques: In Vitro, Ex Vivo, Injection, Imaging, Mouse Assay, Plasmid Preparation, Modification, Recombinant, Diagnostic Assay, Virus, Sonication, Amplification, Magnetic Resonance Imaging

Journal: Aesthetic Surgery Journal

Article Title: Effect of a Facial Muscle Exercise Device on Facial Rejuvenation

doi: 10.1093/asj/sjx238

Figure Lengend Snippet: Measurement of the thickness of the levator labii superioris and orbicularis oris muscles using ultrasound images of a 30-year-old woman. (A) Anatomical position of the levator labii superioris muscle, (B) probe position for the levator labii superioris and muscle thickness of the levator labii superioris (C) initially and (D) after the sessions; (E) anatomical position of the orbicularis oris muscle, (F) probe position for the orbicularis oris and muscle thickness of orbicularis oris (G) initially, and (H) after the sessions.

Article Snippet: Ultrasound images of the facial muscles (levator labii superioris, orbicularis oris, zygomaticus major, and, among the suprahyoid muscles, the digastric muscle) were obtained using a diagnostic ultrasound system (A35; Samsung Medison, Seoul, Korea) that included a 3-16 MHZ probe (LA3-16A).

Techniques: Muscles

Journal: Aesthetic Surgery Journal

Article Title: Effect of a Facial Muscle Exercise Device on Facial Rejuvenation

doi: 10.1093/asj/sjx238

Figure Lengend Snippet: Measurement of the cross-sectional area of the zygomaticus major and digastric muscles using ultrasound images of a 30-year-old woman. (A) Anatomical position of the zygomaticus major muscle, (B) probe position for the digastric muscle, cross-sectional area of the digastric muscle, (C) cross-sectional area of the zygomaticus major initially, and (D) after the sessions, (E) anatomical position of the digastric muscle, (F) probe position for the zygomaticus major, (G) initially, and (H) after the sessions.

Article Snippet: Ultrasound images of the facial muscles (levator labii superioris, orbicularis oris, zygomaticus major, and, among the suprahyoid muscles, the digastric muscle) were obtained using a diagnostic ultrasound system (A35; Samsung Medison, Seoul, Korea) that included a 3-16 MHZ probe (LA3-16A).

Techniques: Muscles

Journal: Brain stimulation

Article Title: Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load, chronically, as demonstrated in vivo.

doi: 10.1016/j.brs.2020.03.016

Figure Lengend Snippet: (A) This figure shows the transducer portion of the entire tFUS device below a mathematical representation of the two-annular transducer (red and blue circles) beneath a planar representation of the focal volume of ultrasound. (B) This figure shows a closeup of a mathematical representation of the maximum pressure field generated within the focal region of our ultrasound source as if it were measured in water. (C) This figure shows the working end of the tFUS device (top) with water-filled cone and closing membrane over ultrasound field of (B) itself superimposed upon a coronal slice of mouse brain, to scale.

Article Snippet: Given the existence of relatively inexpensive and highly portable diagnostic ultrasound devices (Butterfly IQ, Lumify, SonoSite, Vscan, among others), results such as ours could one day lead to rapid production of tFUS devices capable of addressing Alzheimer’s Disease.

Techniques: Generated, Membrane

Journal: Brain stimulation

Article Title: Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load, chronically, as demonstrated in vivo.

doi: 10.1016/j.brs.2020.03.016

Figure Lengend Snippet: This figure shows our measurement of brain activity between two electrodes generated by transcranial, focused ultrasound whose delivery starts at the 1.0 second mark and ends by 6.0 seconds. Here we have averaged the difference in data streams between each visual cortex of one sedated mouse over a 17 minutes window within an hour-long delivery of tFUS. The frequency with the largest signal is centered on 40 Hz, the pulse repetition frequency of the ultrasound.

Article Snippet: Given the existence of relatively inexpensive and highly portable diagnostic ultrasound devices (Butterfly IQ, Lumify, SonoSite, Vscan, among others), results such as ours could one day lead to rapid production of tFUS devices capable of addressing Alzheimer’s Disease.

Techniques: Activity Assay, Generated